| Autor: |
Šiftar, Z., Kardum, M-M., Nazor, A., Bobetić-Vranić, T., Flegar-Meštrić, Z., Kardum-Skelin, I., Šušterčić, D., Minigo, H., Jakšić, B., Planinc- Peraica, A., Ostojić-Kolonić, S., Vrhovac, R. |
| Přispěvatelé: |
Italian Society of Clinical Biochemistry |
| Jazyk: |
angličtina |
| Rok vydání: |
1999 |
| Předmět: |
|
| Popis: |
Flow cytometry techniques (FCM) immunophenotyping, which can be readily performed on the limited size obtained by fine-needle aspirates (FNA), provides more objective information then FNA cytology alone. 87 lymph node FNA specimens from patients suspected having hematological malignancy were analyzed by FCM. Obtained results by FCM were interpreted according either to the normal values for lymph node lymphoid cells reported previously by Bryan et all (Ann. N.Y. Academ.Sci. 1993. 84: 404-406) or to the REAL classification of lymphoid neoplasms. Table 1 presents comparative results obtained by two methods on 87 lymph node FNA specimens: final diagnosisproved by: non-malignant hyperplasia malignant disorder: Hodgkin's disease B-chronic lymphocytic leukemia B-NonHodgkin lymphoma T-Non Hodgkin lymphoma FCM 36 48 0 3 36 6 cytology 36 51 3 3 37 8 agreement 100% 94% 0% 100% 97% 75% In conclusion, FCM is reliable and useful tools for distiguishing reactive and neoplastic processes, in asigment of malignant cells to the B or T cell lineage, even for futher subclassification of disease, but it is not diagnostically helpful in the case of Hodgkin's disease (without agreement with cytomorphology analyses). |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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