| Autor: |
Herman, Mislav, Djelmis, Josip, Berberovic, Edina, Horvaticek, Marina, Ivanisevic, Marina. |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
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| Popis: |
Objective: To investigate the impact of type 1 diabetes mellitus (T1DM) on the fatty acids profile in the maternal and umbilical vein blood. Methods: 60 pregnant women who delivered eutrophic infants (30 pregnant women with T1DM and 30 healthy pregnant women) were included in the study. Immediately after birth maternal and umbilical vein (UV) blood samples were collected. After lipid extraction, gas chromatography was obtained in order to obtain profile of fatty acids in total lipids of maternal and UV serum. Results: Infants of mothers with T1DM had a significantly higher concentration of glucose, C- peptide, leptin, higher ponderal index and higher insulin resistance than infants in the control group (p 0.001). The total concentration of fatty acids in maternal serum did not differ between the experimental groups (p = 0.122). The total concentration of fatty acids in the UV serum was statistically significantly higher in infants born to diabetic mothers compared to the control group (2243.3 ± 177.1: 1360.0 ± 138.0 ; p 0.001). Comparing individual profile of fatty acids in maternal serum of two studied groups, we didn`t find statistically significant difference. When comparing individual fatty acids in the serum of UV, statistically significant differences in almost every fatty acid, except for gamma- linolenic and docosahexaenoic fatty acid (C18: 3n-3 and DHA) was found. Conclusion: Good metabolic control of pregnant women with T1DM has resulted in small and insignificant changes in the maternal blood fatty acids profile and delivery of eutrophic newborns although total concentration of fatty acids in UV serum was still higher when compared to the values from infants born to the healthy mothers. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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