| Autor: |
Krajna, Ana, Pavićević, Radomir, Bubanović, Gordana, Alerić, Ivan, Pavlović, Ladislav, Popović-Grle, Sanja |
| Přispěvatelé: |
Sterk, Peter J, Rabe, Klaus F |
| Jazyk: |
angličtina |
| Rok vydání: |
2003 |
| Předmět: |
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| Popis: |
Introduction: Single pulmonary nodules (SPNs) still represent a great challenge in pulmonary diadnostics. Biodynamic approach has been applied to determine wether tumor marker CYFRA 21-1 can be used as an early parameter of separation of non-small cell lung camcer (NSCLC) from other SPNs. Patients&methods: The study includes 431 patients with radiological finding of SPN that is not suitable from transthoracic and videothoracoscopic diagnostics. CYFRA 21-1 level was measured by electrochemiluminescent immunoassay at first admission and durinfg the first control check (1-3 months later). After taht period, the final diagnosis has been made and all the patient underwent surgical treatment. eight pathohistological groups were obtained after the surgery: carcinoid tumor, hamartoma, adenocarcinoma stage IA and IB, Squamous cell carcinoma stage IA, Hodgkin's diseases, pulmonary metastases and tuberculoma. Results: Kruskal-Wallis ANOVA proved significantd differences between 8 groups, both in first and second measurement (p=0, 0001). Patients with AD IB showed the greatest distinction from all other groups. Comparison of all other groups with each other showed the most discriminatory power of difference between two measurements. Patients with NSCLC differed significantly from all other groups, but did not differ between themselves. Conclusions: CYFRA 21-1 can be used in differential diagnosis of SPNs for early detection of NSCLC using two measurements because the dynamics of CYFRA 21-1 level divides primary NSCLC from other SPNs. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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