| Autor: |
Hammer, Arne, Hodgson, David R. W., Cann, Martin J. |
| Zdroj: |
Biochemical Journal; June 2006, Vol. 396 Issue: 2 p215-218, 4p |
| Abstrakt: |
The Slr1991 adenylyl cyclase of the model prokaroyte Synechocystis PCC 6803 was stimulated 2-fold at 20 mM total Ci (inorganic carbon) at pH 7.5 through an increase in kcat. A dose response demonstrated an EC50 of 52.7 mM total Ci at pH 6.5. Slr1991 adenylyl cyclase was activated by CO2, but not by HCO3−. CO2 regulation of adenylyl cyclase was conserved in the CyaB1 adenylyl cyclase of Anabaena PCC 7120. These adenylyl cyclases represent the only identified signalling enzymes directly activated by CO2. The findings prompt an urgent reassessment of the activating carbon species for proposed HCO3−-activated adenylyl cyclases. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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