| Autor: |
Bertoni-Freddari, Carlo, Fattoretti, Patrizia, Giorgetti, Belinda, Grossi, Yessica, Balietti, Marta, Casoli, Tiziana, Stefano, Giuseppina Di, Perretta, Gemma |
| Zdroj: |
Rejuvenation Research; Spring 2006, Vol. 9 Issue: 1 p85-88, 4p |
| Abstrakt: |
Synaptic numeric density (Nv), average size (area: S), surface density (Sv) and number of synapses/neurone (Syn/Neur) were morphometrically measured in frontal (FC) and temporal (TC) cortex of adult and old monkeys. Sv was constant, a clear age-related trend to decrease by Nv and increase by S were observed in both areas investigated. Syn/Neur significantly decreased in TC of aged animals (–21.1%), whereas FC showed a not significant reduction (–2.6%). The present data support the hypothesis of an increased sensitivity to deterioration of TC synapses in aged monkeys, which might constitute a predisposing condition to the development of senile plaques. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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