| Autor: |
Jara, Aquiles, von Höveling, Andrea, Jara, Ximena, Burgos, M Eugenia, Valdivieso, Andres, Mezzano, Sergio, Felsenfeld, Arnold J |
| Zdroj: |
Nephrology Dialysis Transplantation; April 2006, Vol. 21 Issue: 4 p917-923, 7p |
| Abstrakt: |
A variety of stimuli are involved in the pathogenesis of parathyroid gland hyperplasia in renal failure. Recently, it was shown that blocking the signal from the endothelin-1 (ET-1) receptor (ET(A)R/ET(B)R) by a non-selective receptor antagonist, bosentan, reduced parathyroid cell proliferation, parathyroid gland hyperplasia and parathyroid hormone (PTH) levels in normal rats on a calcium deficient diet. Our goal was to determine whether in 5/6 nephrectomized (NPX) rats with developing or established hyperparathyroidism, the endothelin receptor blocker, bosentan, reduced the increase in parathyroid cell proliferation, parathyroid gland hyperplasia and PTH values. |
| Databáze: |
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