A Structurally Diverse Library of Polycyclic Lactams Resulting from Systematic Placement of Proximal Functional GroupsThis work was conducted under the aegis of the Harvard Center for Methodology and Library Development (NIGMS P50 GM069721). J.T.S. thanks Amgen Pharmaceuticals for a New Faculty Award. We thank Prof. Nabi Magomedov (Rochester University), Dr. Jacob Janey (Merck), Prof. Timothy J. Mitchison (Harvard Medical School), and Professor Stuart Schreiber (Broad Institute) for insightful discussions. The authors thank Max Narovlyansky for the preparation of the solid support, Dr. Nicola J. Tolliday (Broad Institute) for facilitation of screening, and Dr. Ralph Mazitschek (Broad Institute) for assistance with molecular modeling.

Autor:	Mitchell, Judith M., Shaw, Jared T.
Zdroj:	Angewandte Chemie. International Edition; March 2006, Vol. 45 Issue: 11 p1722-1726, 5p
Abstrakt:	No Abstract
Databáze:	Supplemental Index
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