THERAPEUTIC STRATEGIES FOR THE INHIBITION OF INDUCIBLE NITRIC OXIDE SYNTHASE—POTENTIAL FOR A NOVEL CLASS OF ANTI-INFLAMMATORY AGENTS

Autor:	PFEILSCHIFTER, JOSEF, EBERHARDT, WOLFGANG, HUMMEL, RICHARD, KUNZ, DIETER, MÜHL, HEIKO, NITSCH, DOROTHEA, PLÜSS, CHRISTOPH, WALKER, GABY
Zdroj:	Cell Biology International; January, 1996, Vol. 20 Issue: 1 p51-58, 8p
Abstrakt:	In recent years, NO, a gas previously considered a potentially toxic chemical, has become established as a diffusible universal messenger mediating cell–cell communication throughout the body. In mammals, NO is a recognized mediator of blood vessel relaxation that helps to maintain blood pressure. In the central nervous system NO acts as a non-conventional neurotransmitter and participates in the establishment of long-term plasticity required for memory formation. In addition, NO is responsible for some parts of the host response to sepsis and inflammation and contributes to certain disease states. A number of strategies have emerged with regard to a pharmacological control of pathological NO overproductions. This review will discuss these novel therapeutic approaches that may provide new means for clinical medicine.
Databáze:	Supplemental Index
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