| Autor: |
Artola, Rodolfo L., Conde, Cecilia B., Bagatolli, Luis, Pécora, Rolando P., Fidelio, Gerardo D., Kivatinitz, Silvia C. |
| Zdroj: |
Biochemical and Biophysical Research Communications; October 1997, Vol. 239 Issue: 2 p570-574, 5p |
| Abstrakt: |
Oxidized lipoproteins have been involved in the pathogenesis of atherosclerosis and atherosclerotic lesions contain oxidized low density lipoprotein. Conversely, the presence of oxidized high density lipoprotein (HDL)in vivohas not been clearly established. Oxidation of HDLin vitromodels produces an increase in peroxidized lipids and the appearance of apolipoprotein A-I (apo A-I) oligomers. We investigated the oxidative status of HDL in anin vivomodel: the hypercholesterolemic chicken. The HDLs from control and hyperlipemic animals were analyzed for the content of lipid peroxides employing spectroscopic and fluorescence techniques, for the level of apo A-I oligomerization, and for susceptibility toin vitrooxidation. HDL from hypercholesterolemic chickens was more peroxidized (as detected by fluorescence), had higher amount of oligomeric apo A-I, and was oxidized to a greater extent by uv irradiation than that of control animals. We speculate that apo A-I oligomerization could be a key step in the atheroma formation. |
| Databáze: |
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