| Autor: |
Kumar, N., Kiuchi, M., Tallarico, J. A., Schreiber, S. L. |
| Zdroj: |
Organic Letters; June 2005, Vol. 7 Issue: 13 p2535-2538, 4p |
| Abstrakt: |
We describe a short synthetic sequence resulting in >4000 skeletally diverse small molecules that have three distinct skeletal frameworks among other unique structural features. The sequence entails skeletal transformations pioneered by Winterfeldt and co-workers. We use epoxide ring openings and subsequent functionalizations that provide, e.g., spirocyclic oxazolidines, Lewis acid catalyzed Diels−Alder reactions of a steroid-derived diene that afford stable and isolable ring B adducts, and subsequent retro-Diels−Alder fragmentations that yield 14-membered paracyclophanes. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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