| Autor: |
Nakamura, Masahiko, Takahashi, Tetsufumi, Matsumoto, Tsukasa, Atsuda, Koichiro, Hibi, Norifumi, Matsui, Hidenori, Yamada, Haruki, Tsuchimoto, Kanji |
| Zdroj: |
Digestive Diseases and Sciences; October 2005, Vol. 50 Issue: Supplement 1 pS113-S118, 6p |
| Abstrakt: |
Abstract To determine the effects of rebamipide during the early stages of colitits development, colitis was induced in rats by oral administration of dextran sulfate sodium for 3 or 7 days. The target sites of 3H-rebamipide were examined by intra-aortic infusion of the radiolabeled compound followed by autoradiography. 3H-rebamipide was localized in goblet cells in the colon of the control rat, whereas it accumulated in the cytoplasm of mesenchymal cells in dextran sulfate sodium treated rats, localized predominatly to polymorphonuclear leucocytes. |
| Databáze: |
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