| Autor: |
Perez, Richard, Johnson, Jeremy, Winkler, James D., Rudich, Steven, Carter, Lynn, Katznelson, Steven, German, J.Bruce |
| Zdroj: |
Journal of Surgical Research; July 1998, Vol. 78 Issue: 1 p37-41, 5p |
| Abstrakt: |
Background.Kupffer cells, after exposure to alloantigen via the portal vein, mediate an immunosuppressive effect involving enhanced production of PGE2. We hypothesize that up-regulation of Kupffer cell CoA-independent transacylase (CoA-IT) by portal venous transfusion (PVT) is a possible mechanism of increased PGE2production. Additionally, enhanced lymphocyte apoptosis, a process known to be macrophage dependent and facilitated by PGE2, is postulated as a possible mechanism of PVT-induced, Kupffer cell-mediated immunosuppression. |
| Databáze: |
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