Simvastatin attenuates renal inflammation, tubular transdifferentiation and interstitial fibrosis in rats with unilateral ureteral obstruction.

Autor: Vieira, José Mauro, Mantovani, Eduardo, Rodrigues, Leonardo Tavares, Dellê, Humberto, Noronha, Irene Lourdes, Fujihara, Clarice Kazue, Zatz, Roberto
Zdroj: Nephrology Dialysis Transplantation; August 2005, Vol. 20 Issue: 8 p1582-1591, 10p
Abstrakt: The pleiotropic actions of statins have been largely explored. These drugs have been tested in several models of progressive renal disease, most of them accompanied by hypertension. We sought to investigate more closely the effects of simvastatin on renal interstitial fibrosis due to unilateral ureteral obstruction (UUO).
Databáze: Supplemental Index