| Abstrakt: |
After a hyperglycaemic episode, glycated proteins remain in the body until removed by protein turnover. We have shown that in the absence of free sugar, such proteins can crosslink to native proteins, forming mixed dimers. They can also induce native proteins to crosslink into homodimers, presumably by release of a soluble crosslinking agent. Similar reactionsin vivocould be responsible for the deposition of serum proteins in diabetic kidney, nerve and other tissues. Exposure to glycating sugar for brief periods, or at low concentration, still produced glycated protein capable of crosslinking to other proteins under sugar-free conditions. These crosslinks are nonfluorescent, unlike the advanced glycation endproducts usually observed. |
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