| Autor: |
Nickel, Peter, Kreutzer, Stephanie, Bold, Gantuja, Friebe, Astrid, Schmolke, Kathrin, Meisel, Christian, Jurgensen, Jan Steffen, Thiel, Andreas, Wernecke, Klaus-Dieter, Reinke, Petra, Volk, Hans-Dieter |
| Zdroj: |
American Journal of Transplantation; July 2005, Vol. 5 Issue: 7 p1764-1771, 8p |
| Abstrakt: |
Little is known about thymus function in transplant patients. Until recently, the phenotype of T cells that recently emigrated the thymus was unknown. Now it has been demonstrated that CD4+ recent thymus emigrants coexpress CD31 and CD45RA. Here, we investigated whether uremia and immunosuppression influence CD31+ CD45RA+ Th cells before and after kidney transplantation, respectively. Forty-eight renal transplant patients were included receiving either standard triple/quadruple (n = 35) immunosuppression, OKT-3 induction (n = 7) or FTY-720 (n = 6), respectively. Peripheral CD31+ CD45RA+ Th cells were quantified flowcytometrically before and at week 1, 4, 12 and 24 post-transplantation. Thirty-nine healthy adults served as controls. CD31+ CD45RA+ Th cells correlated inversely with age in patients and controls and were comparable in patients before transplantation and age-matched controls. Importantly, CD31+ CD45RA+ Th cell frequencies remained stable during 6 months post-transplantation. In conclusion, CD31+ CD45RA+ Th cells are not significantly altered by uremia before and during 6 months of immunosuppressive therapy after kidney transplantation. Implications for thymus function are discussed. |
| Databáze: |
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