ELECTIVE ORTHOPEDIC SURGERY, A MODEL FOR THE STUDY OF CYTOKINE ACTIVATION AND REGULATION

Autor: Van Deuren, M., Twickler, Th.B., de Waal Malefyt, M.C., Van Beem, H., van der Ven-Jongekrijg, J., Verschueren, C.M.M., van der Meer, J.W.M.
Zdroj: Cytokine; November 1998, Vol. 10 Issue: 11 p897-903, 7p
Abstrakt: Induction and downregulation of cytokine production occurs after contact with various inflammatory stimuli. To elucidate the early events after a physical stressor, we studied these processes in 13 patients undergoing elective total hip replacement surgery. In these patients we followed the plasma concentrations of tumour necrosis factor α (TNF), interleukin 1β (IL-1β), IL-6 and IL-1 receptor antagonist (IL-1Ra), mRNA for these cytokines in peripheral blood cells (PBCs), and the lipopolysaccharide(LPS)-stimulated ex vivo production of these cytokines in whole blood cultures (WBCs).
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