| Autor: |
Bunchman, Timothy E., Lynch, Robert E., Garvin, Paul J., Fleming, Susan S., Wood, Ellen G. |
| Zdroj: |
Clinical Transplantation; February 1992, Vol. 6 Issue: 1 p27-30, 4p |
| Abstrakt: |
We reviewed the renal allograft length as determined by serial ultrasound examinations in 12 children who underwent renal transplantation at less than 4 years of age (18.1 ± 4.1 months, 9.48 ± 0.78 kg, mean ± SEM) receiving an adult donor kidney. Follow‐up serum creatinines and allograft length, (determined by ultrasounds) were reviewed for a mean of 59.7 ± 7.4 months after transplantation. Nine of 12 children have stable allograft function whereas 3/12 children have functional deterioration with histological evidence of chronic rejection. Compared to baseline, in those children with stable function there was a mean decrease in allograft length (–0.7 ± 0.1 cm) at 1 yr post‐transplantation with return to baseline allograft length at 4 yr (+0.2 ± 0.2 cm). Beyond 4 yr, there is a persistent increase in allograft length of +0.6 ± 0.3, +1.3 ± 0.6 and + 1.9 ± 0.5 cm as compared to baseline at 5, 6 and 7 yr respectively (p < 0.01). This is in contrast to a persistent diminution in allograft length with failure to return to baseline length in those children with chronic rejection. In this small number of young children there appears to be growth potential over time of the donor adult allograft with stable function, which appears to be lacking in those allografts with chronic rejection. The stimulus for the allograft growth may be due to unique growth factors that are yet to be determined. |
| Databáze: |
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