| Autor: |
Takewaki, Daiki, Kiguchi, Yuya, Masuoka, Hiroaki, Manu, Mallahalli, Raveney, Ben J.E., Narushima, Seiko, Kurokawa, Rina, Ogata, Yusuke, Kimura, Yukio, Sato, Noriko, Ozawa, Yusuke, Yagishita, Sosuke, Araki, Toshiyuki, Miyake, Sachiko, Sato, Wakiro, Suda, Wataru, Yamamura, Takashi |
| Zdroj: |
Cell Reports; 20240101, Issue: Preprints |
| Abstrakt: |
Multiple sclerosis (MS) is an autoimmune demyelinating disease with the inflammatory pathology formed by self-reactive lymphocytes with activated glial cells. Progressive MS, characterized by resistance to medications, significantly differs from the non-progressive form in gut microbiome profiles. After confirming an increased abundance of “Tyzzerella nexilis”in various cohorts of progressive MS, we identified a distinct cluster of T. nexilisstrains enriched in progressive MS based on long-read metagenomics. The distinct T. nexiliscluster is characterized by a large number of mobile genetic elements (MGEs) and lack of defense systems against MGE. Microbial genes for sulfate reduction and flagella formation with pathogenic implications are specific to this cluster. Moreover, these flagellar genes are encoded on MGEs. Mono-colonization with MGE-enriched T. nexilismade germ-free mice more susceptible to experimental autoimmune encephalomyelitis. These results indicate that progression of MS may be promoted by MGE-enriched T. nexiliswith potentially pathogenic properties. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
