| Autor: |
Tochikura, Naohiro, Matsumoto, Chiaki, Iwabuchi, So, Aso, Hiroya, Fukushima, Sakae, Ootsuka, Susumu, Ooba, Nobuhiro, Ishihara, Masaki, Nakajima, Hideto, Umemura, Hiroshi, Nakayama, Tomohiro |
| Zdroj: |
European Journal of Hospital Pharmacy : Science and Practice; 2024, Vol. 31 Issue: 5 p440-446, 7p |
| Abstrakt: |
ObjectivesThe trough concentration of vancomycin and the area under the concentration–time curve (AUC)/minimum inhibitory concentration (MIC) ratio are crucial in determining vancomycin efficacy against methicillin-resistant Staphylococcus aureus. However, the use of similar pharmacokinetic principles in determining antibiotic efficacy against other gram-positive cocci is lacking. We performed a pharmacokinetic/pharmacodynamic analysis (association of target trough concentration values and AUC/MIC with therapeutic outcome) of vancomycin in patients with Enterococcus faeciumbacteraemia.MethodsBetween January 2014 and December 2021 we performed a retrospective cohort study of patients with E. faeciumbacteraemia treated with vancomycin. Patients who received renal replacement therapy or had chronic kidney disease were excluded. Clinical failure, the primary outcome, was defined as a composite of 30-day all-cause mortality, vancomycin-susceptible infection requiring change of treatment, and/or recurrence. AUC24was estimated using a Bayesian estimation approach based on an individual vancomycin trough concentration. The MIC for vancomycin was determined using a standardised agar dilution method. Additionally, classification was used to identify the vancomycin AUC24/MIC ratio associated with clinical failure.ResultsOf the 151 patients identified, 69 were enrolled. All MICs of vancomycin for E. faeciumwere ≤1.0 µg/mL. The AUC24and AUC24/MIC ratio were not significantly different between the clinical failure group and the clinical success group (432±123 µg/mL/hour vs 488±92 µg/mL/hour; p=0.075). However, 7 of 12 patients (58.3%) in the clinical failure group and 49 of 57 patients (86.0%) in the clinical success group had a vancomycin AUC24/MIC ratio ≥389 (p=0.041). No significant association between trough concentration or AUC24≥600 µg/mL×hour and acute kidney injury was observed (p=0.365 and p=0.487, respectively).ConclusionThe AUC24/MIC ratio is associated with the clinical outcome of vancomycin administration in E. faeciumbacteraemia. In Japan, where vancomycin-resistant enterococcal infection is rare, empirical therapy with a target AUC24≥389 should be recommended. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
