| Autor: |
Deviprasad, M. J., Hemanth, B. S., Shivaswamy, M. B., Nagendra Prasad, H. S., Sumathi, Sundaravadivelu, Aswathy, R., Sangamesha, M. A., Ananda, A. P., Jayanth, H. S., Lohith, T. N. |
| Zdroj: |
BioNanoScience; 20240101, Issue: Preprints p1-16, 16p |
| Abstrakt: |
The present study reports the synthesis of multifunctional silver nanoparticles using citral–tryptamine (CT@AgNPs). In this approach, synthesis of citral–tryptamine-based Schiff base (CT) was characterized using various spectral studies such as NMR, FT-IR, and LCMS. The various biological properties were investigated using ADME, Bioactive, and molecular docking analysis of CT compound. Interaction and binding affinities toward protein IDs 6SJA and 3DAQ were significant. Silver nanoparticles were synthesized by reduction method using CT compound and confirmed by XRD, EDX, SEM, and DLS analysis. Herein, CT@AgNPs have an average diameter of 52 nm. The silver nanoparticle exhibited enhanced antibacterial activity against methicillin-resistant Staphylococcus aureus(MRSA); the MIC value is 15 ± 0.50 µg/mL. These nanoparticles showed remarkable toxic effect against SiHacervical cancer cell line, and obtained IC50value is 100 µg/mL. Additionally, we propound the rapid, sensitive, and cost-effective electrochemical approach for detection of nitrite with linear dynamic range of 0.4 to 4.0 mM with a lower detection limit of 0.4 mM. These results advocate promising antibacterial and anticancer properties of CT@AgNPs for futuristic therapeutics and sensor application. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
Full text from SpringerLink