| Autor: |
Berube, Benjamin, Ernst, Evan, Cahn, Jonathan, Roche, Benjamin, de Santis Alves, Cristiane, Lynn, Jason, Scheben, Armin, Grimanelli, Daniel, Siepel, Adam, Ross-Ibarra, Jeffrey, Kermicle, Jerry, Martienssen, Robert A. |
| Zdroj: |
Nature; September 2024, Vol. 633 Issue: 8029 p380-388, 9p |
| Abstrakt: |
Selfish genetic elements contribute to hybrid incompatibility and bias or ‘drive’ their own transmission1,2. Chromosomal drive typically functions in asymmetric female meiosis, whereas gene drive is normally post-meiotic and typically found in males. Here, using single-molecule and single-pollen genome sequencing, we describe Teosinte Pollen Drive, an instance of gene drive in hybrids between maize (Zea maysssp. mays) and teosinte mexicana(Z. maysssp. mexicana) that depends on RNA interference (RNAi). 22-nucleotide small RNAs from a non-coding RNA hairpin in mexicanadepend on Dicer-like 2(Dcl2) and target Teosinte Drive Responder 1(Tdr1), which encodes a lipase required for pollen viability. Dcl2, Tdr1and the hairpin are in tight pseudolinkage on chromosome 5, but only when transmitted through the male. Introgression of mexicanainto early cultivated maize is thought to have been critical to its geographical dispersal throughout the Americas3, and a tightly linked inversion in mexicanaspans a major domestication sweep in modern maize4. A survey of maize traditional varieties and sympatric populations of teosinte mexicanareveals correlated patterns of admixture among unlinked genes required for RNAi on at least four chromosomes that are also subject to gene drive in pollen from synthetic hybrids. Teosinte Pollen Driveprobably had a major role in maize domestication and diversification, and offers an explanation for the widespread abundance of ‘self’ small RNAs in the germ lines of plants and animals. |
| Databáze: |
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| Externí odkaz: |
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