Influence of TP53gene mutations and their allelic status in myelodysplastic syndromes with isolated 5q deletion

Autor: Montoro, Maria Julia, Palomo, Laura, Haferlach, Claudia, Acha, Pamela, Chan, Onyee, Navarro, Víctor, Kubota, Yasuo, Schulz, Felicitas Isabel, Meggendorfer, Manja, Briski, Robert, Al Ali, Najla, Xicoy, Blanca, López-Cadenas, Félix, Bosch, Francesc, González, Teresa, Eder, Lea Naomi, Jerez, Andrés, Wang, Yu-Hung, Campagna, Alessia, Santini, Valeria, Bernal del Castillo, Teresa, Such, Esperanza, Tien, Hwei-Fang, Diaz Varela, Nicolás, Platzbecker, Uwe, Haase, Detlef, Díez-Campelo, María, Della Porta, Matteo, Garcia-Manero, Guillermo, Wiseman, Daniel H., Germing, Ulrich, Maciejewski, Jaroslaw P., Komrokji, Rami S., Sole, Francesc, Haferlach, Torsten, Valcárcel, David
Zdroj: Blood; October 2024, Vol. 144 Issue: 16 p1722-1731, 10p
Abstrakt: •TP53allelic state and VAF significantly correlates with outcomes in patients with MDS-del(5q).•Based on TP53allelic status and a VAF cutoff of 20%, 2 distinct groups with clinical implications are identified among MDS-del(5q).
Databáze: Supplemental Index