Discovery of Pyrano[3,4-b]indoles as Potent and Selective HCV NS5B Polymerase Inhibitors

Autor: Gopalsamy, A., Lim, K., Ciszewski, G., Park, K., Ellingboe, J. W., Bloom, J., Insaf, S., Upeslacis, J., Mansour, T. S., Krishnamurthy, G., Damarla, M., Pyatski, Y., Ho, D., Howe, A. Y. M., Orlowski, M., Feld, B., O'Connell, J.
Zdroj: Journal of Medicinal Chemistry; December 2004, Vol. 47 Issue: 26 p6603-6608, 6p
Abstrakt: A novel series of HCV NS5B RNA-dependent RNA polymerase inhibitors containing a pyrano[3,4-b]indole scaffold is described leading to the discovery of compound 16, a highly potent and selective inhibitor that is active in the replicon system.
Databáze: Supplemental Index