Autor: |
Gopalsamy, A., Lim, K., Ciszewski, G., Park, K., Ellingboe, J. W., Bloom, J., Insaf, S., Upeslacis, J., Mansour, T. S., Krishnamurthy, G., Damarla, M., Pyatski, Y., Ho, D., Howe, A. Y. M., Orlowski, M., Feld, B., O'Connell, J. |
Zdroj: |
Journal of Medicinal Chemistry; December 2004, Vol. 47 Issue: 26 p6603-6608, 6p |
Abstrakt: |
A novel series of HCV NS5B RNA-dependent RNA polymerase inhibitors containing a pyrano[3,4-b]indole scaffold is described leading to the discovery of compound 16, a highly potent and selective inhibitor that is active in the replicon system. |
Databáze: |
Supplemental Index |
Externí odkaz: |
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