Stereotactic radiotherapy for neovascular age-related macular degeneration (STAR): a pivotal, randomised, double-masked, sham-controlled device trial

Autor: Jackson, Timothy L, Desai, Riti, Wafa, Hatem A, Wang, Yanzhong, Peacock, Janet, Peto, Tunde, Chakravarthy, Usha, Dakin, Helen, Wordsworth, Sarah, Lewis, Cornelius, Clinch, Patricia, Ramazzotto, Lisa, Neffendorf, James E, Lee, Chan Ning, O'Sullivan, Joe M, Reeves, Barnaby C, Abugreen, Salwa, Bindra, Mandeep, Burton, Ben, Dias, Indra, Dinah, Christiana, Gandhewar, Ravikiran, Georgas, Athanasios, Goverdhan, Srinivas, Gulrez, Ansari, Haynes, Richard, Hughes, Edward, Jackson (Chief Investigator), Timothy, Jafree, Afsar, Joseph, Sobha, Kashab, Tarek, Membrey, Luke, Menon, Geeta, Misra, Aseema, Narendran, Niro, Newman, Douglas, Patel, Jignesh, Patra, Sudeshna, Petrarca, Robert, Priya, Prakash, Rashi, Arora, Salom, Ramiro, Shah, Paritosh, Shahrnaz, Izadi, Sheen, George, Shiew, Marianne, Tesha, Paul, Vrizidou, Eleni
Zdroj: The Lancet; 20240101, Issue: Preprints
Abstrakt: Neovascular age-related macular degeneration (nAMD) is a leading cause of blindness. The first-line therapy is anti-vascular endothelial growth factor (anti-VEGF) agents delivered by intravitreal injection. Ionising radiation mitigates key pathogenic processes underlying nAMD, and therefore has therapeutic potential. STAR aimed to assess whether stereotactic radiotherapy (SRT) reduces the number of anti-VEGF injections required, without sacrificing visual acuity.
Databáze: Supplemental Index