Structural differences in the cell binding region of human fibronectin molecules isolated from cultured normal and tumor-derived human cells

Autor: Borsi, Laura, Allemanni, Giorgio, Castellani, Patrizia, Rosellini, Claudio, Di Vinci, Angela, Zardi, Luciano
Zdroj: FEBS Letters; January 1985, Vol. 192 Issue: 1 p71-74, 4p
Abstrakt: Fibronectins isolated from human plasma (pFN) and from the conditioned media of normal (N-cFN) and tumor (T-cFN) human cells were compared by cathepsin D digestion followed by immunostaining of released fragments with the monoclonal antibody 3E3, specific for the cell binding site. Two different staining patterns were obtained, one specific for pFN and N-cFN, the second common to fibronectins from the 3 different kinds of tumors studied. This indicates structural differences between N-cFN and T-cFN in the cell binding region of the fibronectin molecule.
Databáze: Supplemental Index