| Autor: |
Ciuffoli, Veronica, Feng, Xuesong, Jiang, Kan, Acevedo-Luna, Natalia, Ko, Kyung Dae, Wang, A. Hong Jun, Riparini, Giulia, Khateb, Mamduh, Glancy, Brian, Dell'Orso, Stefania, Sartorelli, Vittorio |
| Zdroj: |
Genes & Development; 2024, Vol. 38 Issue: 3-4 p151-167, 17p |
| Abstrakt: |
In this study, Ciuffoli et al. report that PSAT1, an enzyme of the serine biosynthesis pathway, regulates muscle stem cell proliferation and muscle regeneration by driving production of α-ketoglutarate and glutamine. Their work highlights how cellular metabolism controls stem cell homeostasis and highlights a new therapeutic avenue for reversing the aging-induced decline in muscle regeneration. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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