| Autor: |
Buyukbayram, Mehmet Emin, Hannarici, Zekeriya, Yilmaz, Ali, Turhan, Aykut, Caglar, Alperen Akansel, Esdur, Pınar Coban, Bilici, Mehmet, Tekin, Salim Basol |
| Zdroj: |
Lung Cancer Management; January 2024, Vol. 13 Issue: 1 |
| Abstrakt: |
Aim:The tumor microenvironment of NSCLC with driver mutations, such as EGFR, ALKand ROS, is less inflammatory. Materials & methods:This retrospective study included 38 patients with NSCLC driver mutations. The relationship between clinical and inflammatory markers concerning progression-free survival and overall survival was analyzed based on Kaplan-Meier curves. Results:The mean age of the patients was 59.8 ± 11.9. Progression-free survival and overall survival were significantly longer in patients under 65 years of age and with low neutrophil–lymphocyte ratio, low systemic immune-inflammation index and high lymphocyte count (p < 0.05). Conclusion:Unlike tumor biology, peripheral inflammatory parameters, such as neutrophil–lymphocyte ratio, systemic immune-inflammation index and lymphocyte count may be associated with survival in NSCLC patients with driver mutations. |
| Databáze: |
Supplemental Index |
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