| Autor: |
Sun, Runze, You, Ruixiang, Yu, Xuchang, Zhao, Di, Li, Lei |
| Zdroj: |
Organic Letters; February 2024, Vol. 26 Issue: 7 p1348-1352, 5p |
| Abstrakt: |
The emergence of multidrug-resistant Gram-negative pathogens poses a serious threat to global health. Gram-negative bacteria have become increasingly recognized as underexplored sources of Gram-negative-active cationic lipopeptide (CLP) antibiotics. We systematically screened 8982 sequenced genomes from 42 underexplored Gram-negative bacterial genera and identified eight potential CLP biosynthetic gene clusters. Their predicted products were rapidly accessed by solid-phase total synthesis, which led to the novel antibiotic chospeptin with good activities against clinically isolated colistin-resistant Gram-negative pathogens. |
| Databáze: |
Supplemental Index |
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