Diastereoselective Specificity for the Hydrolysis of Dipeptide Esters in Aqueous Media

Autor: Ueoka, Ryuichi, Goto, Kouichi, Tanoue, Osamu, Miki, Atsushi, Yoshimitsu, Shinya, Imamura, Chikara, Ihara, Yasuji, Murakami, Yukito
Zdroj: Chemistry Letters; January 1999, Vol. 28 Issue: 1 p73-74, 2p
Abstrakt: The diastereoselectivity for the hydrolysis of p-methoxycarbonylphenyl N-(benzyloxycarbonyl)-D(L)-phenylalanyl-L-leucinate in aqueous solution was inverted by changing concentrations of the substrates or the reaction temperature. The monomer-aggregate transition operated on the LL-substrate, which was suggested by the spectroscopic measurements, seems to be responsible for such behavior.
Databáze: Supplemental Index