| Autor: |
Copeland, Karen F.T., Chen, Zhaoxia, Fiebig, Marnie, Ni, Lisa, Savoy, Sherie, Smaill, Fiona M., Rosenthal, Kenneth L., Kim, John E. |
| Zdroj: |
AIDS Research and Human Retroviruses; September 2004, Vol. 20 Issue: 9 p1019-1021, 3p |
| Abstrakt: |
Human immunodeficiency virus type 1 (HIV-1) proviral DNA sequences in the 5′ long terminal repeat (LTR) were examined among 28 drug-naive individuals. Twenty-four subjects had highly conserved LTR sequences, however, more significant changes were observed in the remaining four LTR sequences. These included a 9-bp deletion preceding the NFκB elements and a duplication of the RBF-2 motif. A higher overall frequency of mutations within the LTR occurred within NFAT-1 and Sp-1 sequences. Importantly, a novel 16-bp deletion was found in the distal NFAT-1 site. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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