LepR+niche cell–derived AREG compromises hematopoietic stem cell maintenance under conditions of DNA repair deficiency and aging
| Autor: | Wu, Limei, Lin, Qiqi, Chatla, Srinivas, Amarachintha, Surya, Wilson, Andrew F., Atale, Neha, Gao, Zhenxia J., Joseph, Jonathan, Wolff, Emily V., Du, Wei |
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| Zdroj: | Blood; 20230101, Issue: Preprints |
| Abstrakt: | •Persistent DNA damage induces AREG expression in BM LepR+cells deficient of the Brca2gene.•Overproduced AREG activates the PI3K/AKT/mTOR pathway, promotes HSC cycling, and compromises HSC quiescence in LepR-Cre;Brca2fl/flmice. |
| Databáze: | Supplemental Index |
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