Combined mutations of the penAwith ftsXgenes contribute to ceftriaxone resistance in Neisseria gonorrhoeaeand peptide nucleic acids targeting these genes reverse ceftriaxone resistance

Autor:	Zhu, Lin, Liang, Jingyao, Zheng, Yue, Chen, Shaochun, Xu, Qingfang, Yin, Songchao, Hong, Yiyong, Cao, Wenling, Lai, Wei, Gong, Zijian
Zdroj:	Journal of Global Antimicrobial Resistance; December 2023, Vol. 35 Issue: 1 p19-25, 7p
Abstrakt:	•penA-A501T reduces gonococcal susceptibility to ceftriaxone.•ftsX-R251H cooperates with penA-A501T to produce ceftriaxone resistance in gonococci.•asPNAs targeting these genes can effectively reverse ceftriaxone resistance.
Databáze:	Supplemental Index
Externí odkaz:	Zobrazit plný text záznamu Full Text from ScienceDirect