| Abstrakt: |
Abstract : In the current research, the preparation and characterization of a series of new biocompatible injectable bone paste (IBP) nanocomposites, hydroxyapatite-gelatin (HA-Gel), and hydroxyapatite-gelatin-alendronate (HA-Gel-Ald np) are reported. IBP nanocomposites, HA-Gel np, were synthesized from mixing different ratios of gelatin to aqueous solutions of both Ca(NO3)2.4H2O and (NH4)2HPO4, while the target nanocomposites, HA-Gel-Ald np, were obtained by submitting aqueous solution of alendronate (Ald) to HA-Gel np nanocomposites. This composite crystallinity was analyzed by FTIR and XRD, and their morphology was characterized by scanning electron microscopy (SEM) and EDX measurements. XRD patterns, SEM, and EDX presented changes in the crystal and surface structure from HA to HA-Gel np to HA-Gel-Ald np. These physico-chemical measurements indicated the success in isolating the nanocomposites, HA-Gel np and HA-Gel-Ald np, with different ratios. Furthermore, the cytotoxicity of the nanocomposites on stem cells was assessed using MTT assay. Although the cytotoxicity data show significant effect of the prepared IBP nanocomposites (p= 0.00), their interaction together had no significant effect (p= 0.624). Highlights: • New biocompatible injectable bone paste (IBP) nanocomposites, hydroxyapatite-gelatin (HA-Gel), and hydroxyapatite-gelatin-alendronate (HA-Gel-Ald np). Graphical Abstract: ![]() |
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