| Autor: |
Remore, Luigi Gianmaria, Tolossa, Meskerem, Wei, Wexin, Karnib, Mohammad, Tsolaki, Evangelia, Rifi, Ziad, Bari, Ausaf Ahmad |
| Zdroj: |
Neuromodulation: Technology at the Neural Interface; 20230101, Issue: Preprints |
| Abstrakt: |
Major depression affects millions of people worldwide and has important social and economic consequences. Given up to 30% of patients do not respond to several lines of antidepressive drugs, deep brain stimulation (DBS) has been evaluated for the management of treatment-resistant depression (TRD). The superolateral branch of the medial forebrain bundle (slMFB) appears as a “hypothesis-driven target” because of its role in the reward-seeking system, which is dysfunctional in depression. Although initial results of slMFB-DBS from open-label studies were promising and characterized by a rapid clinical response, long-term outcomes of neurostimulation for TRD deserve particular attention. Therefore, we performed a systematic review focused on the long-term outcome of slMFB-DBS. |
| Databáze: |
Supplemental Index |
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