| Autor: |
Zammit, David J., Berzins, Stuart P., Gill, Jason W., Randle-Barrett, Elise S., Barnett, Louise, Koentgen, Frank, Lambert, Gavin W., Harvey, Richard P., Boyd, Richard L., Classon, Brendan J. |
| Zdroj: |
Molecular and Cellular Biology; February 2002, Vol. 22 Issue: 3 p946-952, 7p |
| Abstrakt: |
Thymic shared antigen 1 (TSA-1) is a plasma membrane protein of the Ly-6 superfamily expressed on thymocytes, thymic stromal cells, and other cells of the hematopoietic system. TSA-1 is also expressed in other nonhematopoietic tissues, in particular, embryonic and adult adrenal glands. To address the function of TSA-1, we generated mutant mice in which TSA-1 expression was inactivated by gene targeting. Here we show that deletion of both TSA-1 alleles results in abnormal adrenal gland development and midgestational lethality due to cardiac abnormalities. We also report that TSA-1-deficient adrenal glands have significantly reduced levels of the catecholamines noradrenaline and adrenaline. We conclude that TSA-1 is required for normal embryonic development but that deletion of its expression does not obviously impair lymphoid development. |
| Databáze: |
Supplemental Index |
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