| Autor: |
Mootoosamy, Covida, Kondyli, Maria, Serfaty, Sophie Annaelle, Tremblay, David-Étienne, Gagné, Vincent, Ribère, Maïté, Laverdière, Caroline, Leclerc, Jean-Marie, Sinnett, Daniel, Tran, Thai Hoa, Krajinovic, Maja |
| Zdroj: |
Pharmacogenomics; March 2023, Vol. 24 Issue: 4 p199-206, 8p |
| Abstrakt: |
Aim:We previously conducted exome-wide association study in acute lymphoblastic leukemia patients and identified association of five SNPs with asparaginase-related thrombosis. Here we aimed to replicate these findings in an independent patient cohort and through analyses in vitro. Patients & methods:SNPs located in IL16, MYBBP1A, PKD2L1, RIN3and MPEG1genes were analyzed in patients receiving Dana-Farber Cancer Institute acute lymphoblastic leukemia treatment protocols 05-001 and 11-001. Thrombophilia-related variations were also analysed. Results:IL16rs11556218 conferred higher risk of thrombosis and higher in vitrosensitivity to asparaginase. The association was modulated by the treatment protocol, risk group and immunophenotype. A crosstalk between factor V Leiden, non-O blood groups and higher risk of thrombosis was also seen. Conclusion:IL16and factor V Leiden variations are implicated in asparaginase-related thrombosis. |
| Databáze: |
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