| Autor: |
Spach, Colette, Aschkenasy, Alexandre |
| Zdroj: |
The Journal of Nutrition; July 1979, Vol. 109 Issue: 7 p1265-1273, 9p |
| Abstrakt: |
The levels of cyclic nucleotides, cAMP and cGMP, were determined in splenic lymphocytes of normally fed (N) and protein deprived (PD) rats before and at different time intervals after a single injection of sheep erythrocytes. Assays were performed with protein binding methods on unseparated as well as on T and B cells fractionated by filtration through nylon wool. The cAMP levels increased in unfractionated cells and in T and B lymphocytes 2 hours following immunization of N rats. Another rise in cAMP levels occurred after 3 days in B lymphocytes, but there was also a simultaneous increase of the cGMP levels in preparations of unfractionated cells and in B lymphocytes. The PD diet suppressed or delayed most of the aforementioned changes. Thus, the immunodepressive effect of such a diet may be ascribed to the inhibition of both the early signal (increase of cAMP levels and of cAMP/cGMP ratio) leading to T and B differentiation and the later signal (increase of cGMP levels) which initiates antibody production. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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