| Autor: |
Brodfuehrer, Joanne I., Zannoni, Vincent G. |
| Zdroj: |
The Journal of Nutrition; February 1987, Vol. 117 Issue: 2 p286-290, 5p |
| Abstrakt: |
Modulation of the flavin-containing monooxygenase (FMO) by varying the ascorbic acid and food intake was investigated. Hepatic activity of the FMO in ascorbic acid-deficient guinea pigs fed a restricted amount of diet, which resulted in a 10–15% body weight loss, was 17% of that in animals fed restricted amounts of the adequate diet. FMO hepatic activity in ascorbic acid-supplemented guinea pigs on a food-restricted regimen was 176% of that found in animals fed the adequate diet ad libitum. This increase in activity was not related to stress. Alteration in the activity of this important drug-metabolizing enzyme system by a combination of ascorbic acid deficiency and reduced food intake could potentially alter the rate of metabolism of a great variety of pharmaceutical drugs and environmental chemicals. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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