Lineage switching of the cellular distribution of BRAFV600Ein multisystem Langerhans cell histiocytosis

Autor: Milne, Paul, Bomken, Simon, Slater, Olga, Kumar, Ashish, Nelson, Adam, Roy, Somak, Velazquez, Jessica, Mankad, Kshitij, Nicholson, James, Yeomanson, Dan, Grundy, Richard, Kamal, Ahmed, Penn, Anthony, Pears, Jane, Millen, Gerard, Morland, Bruce, Hayden, James, Lam, Jason, Madkhali, Maymoon, MacDonald, Jamie, Singh, Preeti, Pagan, Sarah, Rodriguez-Galindo, Carlos, Minkov, Milen, Donadieu, Jean, Picarsic, Jennifer, Allen, Carl, Bigley, Venetia, Collin, Matthew
Zdroj: Blood Advances; May 2023, Vol. 7 Issue: 10 p2171-2176, 6p
Abstrakt: •BRAFV600Ealleles are mainly found in myeloid cells at diagnosis of multisystem LCH.•After more than 2 years, T cells account for 85% of persistent BRAFV600Emutation detected in peripheral blood mononuclear cells.
Databáze: Supplemental Index