Soluble tissue factor is a candidate marker for progression of microvascular disease in patients with Type 2 diabetes

Autor: SOMMEIJER, D.W., HANSEN, H.R., VAN OERLE, R., HAMULYAK, K., VAN ZANTEN, A.P., MEESTERS, E., SPRONK, H.M.H., TEN CATE, H.
Zdroj: Journal of Thrombosis and Haemostasis; March 2006, Vol. 4 Issue: 3 p574-580, 7p
Abstrakt: Objective:To determine the relationship between abnormalities in blood coagulation and prevalent or incident cardiovascular complications in Type 2 diabetes. Design and methods:Prospective cohort study of 128 patients with Type 2 diabetes in whom blood samples were collected at baseline and after 1 year of follow‐up. All cardiovascular complications at baseline and follow‐up were recorded. Forty‐three healthy, age‐matched subjects served as a control group. Results:Logistic analysis revealed an independent relationship between soluble tissue factor (TF) and microvascular disease [per pg mL−1TF: Exp(B) = 1.008; CI(95%)1.002–1.014], or neurogenic disease [Exp(B) = 1.006; CI(95%)1.001–1.011]. The highest levels of soluble TF were observed in patients with microvascular and neurogenic disease (P < 0.001). Patients with Type 2 diabetes having a soluble TF concentration >300 pg mL−1are at a 15‐fold higher risk for the presence of microvascular disease and at a 10‐fold higher risk for the presence of neurogenic disease compared with the patients with concentrations below 100 pg mL−1. Soluble TF was correlated with tissue type plasminogen activator, von Willebrand factor antigen, systolic blood pressure and age. Levels of F1′ + 2, D‐dimer, FVIII activity, t‐PA and vWFag were not different among patients with micro‐, macro‐ or neurogenic complications compared with patients without those complications. Forty‐eight new micro‐, macro‐ and/or neurogenic complications were diagnosed after 1 year follow‐up. With the exception of higher F1 + 2 levels after 1 year all other markers remained unchanged. A trend toward higher soluble TF levels was observed in patients with new microvascular events (P = 0.056). Conclusions:Soluble TF is associated with existing microvascular and neurogenic complications in patients with Type 2 diabetes and is a candidate marker for progression of microvascular disease.
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