| Autor: |
Doan Ngoc, Tra-My, Tilly, Gaëlle, Danger, Richard, Bonizec, Orianne, Masset, Christophe, Guérif, Pierrick, Bruneau, Sarah, Glemain, Alexandre, Harb, Jean, Cadoux, Marion, Vivet, Anaïs, Mai, Hoa Le, Garcia, Alexandra, Laplaud, David, Liblau, Roland, Giral, Magali, Blandin, Stéphanie, Feyeux, Magalie, Dubreuil, Laurence, Pecqueur, Claire, Cyr, Matthew, Ni, Weiming, Brouard, Sophie, Degauque, Nicolas, Blancho, Gilles, Branchereau, Julien, Cantarovich, Diego, Chapelet, Agnès, Dantal, Jacques, Deltombe, Clément, Figueres, Lucile, Garandeau, Claire, Giral, Magali, Gourraud-Vercel, Caroline, Hourmant, Maryvonne, Karam, Georges, Kerleau, Clarisse, Masset, Christophe, Kervela, Delphine, Lebot, Sabine, Meurette, Aurélie, Ville, Simon, Kandell, Christine, Moreau, Anne, Renaudin, Karine, Cesbron, Anne, Delbos, Florent, Walencik, Alexandre, Devis, Anne |
| Zdroj: |
Journal of the American Society of Nephrology; December 2022, Vol. 33 Issue: 12 p2211-2231, 21p |
| Abstrakt: |
The pathogenic role of terminally differentiated effector memory (TEMRA) CD8+T cells has been implicated in kidney transplant failure. The authors showed that humoral rejection of kidney allografts is associated with an accumulation of cytolytic TEMRA CD8+T cells in blood and in kidney graft biopsies. They demonstrated that TEMRA CD8+T cells from kidney transplant recipients exhibit enhanced migratory properties compared with effector memory CD8+T cells and that the chemokine CXCL12 not only promotes migration of TEMRA CD8+T cells toward nonlymphoid organs but also triggers a purinergic P2X4 receptor–dependent proinflammatory response. They also found that agents aimed at potential TEMRA CD8+T cell–specific targets inhibited the migration of TEMRA CD8+T cells from kidney transplant recipients, suggesting a possible strategy in treating kidney transplant failure. |
| Databáze: |
Supplemental Index |
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