| Abstrakt: |
Alzheimer's disease (AD) is an age-related neurodegenerative disease. Prediction and diagnosis of AD, particularly at the early stages, remain challenging due to the lack of biological biomarkers for diagnosis. microRNAs play an essential role in controlling the gene expression level at the post-transcriptional level of mature mRNA and repression of many target genes. In addition, evidence detects that miRNA has a significant role in the biogenesis of AD, which enhances their utility as promising biomarkers for early disease diagnosis, mainly if directly analyzed from circulation. Therefore, we aimed to possibly use miR-125b-5p and miR-146a-5p levels in circulation as novel biomarkers to detect AD. |
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