| Abstrakt: |
In contemporary reports, biosynthesis of plant-mediated nanomaterials using different metals with enormous therapeutic evidences has been well documented in the management of human ailments with little or no records of the involvements of magnesium (Mg). This study therefore aimed at exploring the protective effects of phytomediated magnesium-based nanoparticles using Monodora myristica (M. myristica)seed (Mg(OH)2 NP-Mm) against oxidative damage in tissues of streptozotocin (STZ)-induced diabetic Wistar rats. Mg(OH)2 NP-Mmwas biosynthesized and characterized. Forty-eight adult male Wistar rats weighing 150–200 g were indiscriminately grouped into 8 groups of 6 rats each. Diabetes was induced with a low dose of STZ (55 mg/kg body weight; bw) and diabetic animals administered 50, 100, 150, and 200 mg/kg bw Mg(OH)2 NP-Mmfor 21 days, while control groups received glibenclamide (5 mg/kg bw) and Mg(OH)2-STD (150 mg/kg bw), respectively. However, treatment with Mg(OH)2 NP-Mmcaused a significant (p< 0.05) improvement in fasting blood sugar (FBG), especially in the group administered the highest dose of Mg(OH)2NP-Mmcompared to diabetic (i.e., 297.50 ± 18.63 to 133.50 ± 20.50 mg/ml), serum hepatic biomarkers (ALP, 276.55 ± 11.49 to 151.66 ± 4.00 U/l; AST, 63.13 ± 3.05 to 55.25 ± 12.25; and ALT, 38.75 ± 1.31 to 23.30 ± 7.50 U/l, respectively), renal clearance markers (creatinine and urea), total protein (TP), and bilirubin. Enzymatic and non-enzymatic antioxidants, as well as histomorphological examinations indicated a significant (p< 0.05) restoration of the hepatic, renal, and brain tissue architectures. Overall, cytoprotective effects revealed by Mg(OH)2 NP-Mmvia its ability to mitigate redox imbalance in the tissues examined could probably be responsible for the reversal of FBG in the STZ-induced diabetic rats. |
Full text from SpringerLink