| Autor: |
Duguid, J R, Bohmont, C W, Liu, N G, Tourtellotte, W W |
| Zdroj: |
Proceedings of the National Academy of Sciences of the United States of America; September 1989, Vol. 86 Issue: 18 p7260-7264, 5p |
| Abstrakt: |
We have isolated two recombinant cDNAs whose corresponding RNAs have an increased abundance in scrapie-infected hamster brain. DNA sequence analysis has shown that these two recombinants represent the genes for sulfated glycoprotein 2 and transferrin. The abundance of sulfated glycoprotein 2 RNA is increased in hippocampus from patients with Alzheimer disease and Pick disease, whereas transferrin RNA is not strongly modulated in these conditions. Expression of two previously identified scrapie-modulated genes, encoding glial fibrillary acidic protein and metallothionein, is also increased in both of these neurodegenerative diseases. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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