| Autor: |
Meiri, K F, Pfenninger, K H, Willard, M B |
| Zdroj: |
Proceedings of the National Academy of Sciences of the United States of America; May 1986, Vol. 83 Issue: 10 p3537-3541, 5p |
| Abstrakt: |
Growth-associated protein, GAP-43, is a polypeptide that is induced in neurons when they grow axons. We show by means of subcellular fractionation and immunohistochemical localization that GAP-43 is a component of neuronal growth cones as well as growing neurites; it is similar to a major phosphoprotein, pp46, of a growth cone-enriched subcellular fraction. These conclusions are consistent with the possibility that the induction of GAP-43/pp46 is an important event in the establishment of a productive growth state in which a neuron is competent to extend an axon. |
| Databáze: |
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| Externí odkaz: |
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