NOTCH1 signaling during CD4+T-cell activation alters transcription factor networks and enhances antigen responsiveness

Autor: Wilkens, Alec B., Fulton, Elena C., Pont, Margot J., Cole, Gabriel O., Leung, Isabel, Stull, Sylvia M., Hart, Matthew R., Bernstein, Irwin D., Furlan, Scott N., Riddell, Stanley R.
Zdroj: Blood; November 2022, Vol. 140 Issue: 21 p2261-2275, 15p
Abstrakt: •NOTCH1 signaling restricts naïve CD4+T-cell differentiation and enhances CD4+CAR-T proliferation and helper function.•NOTCH1 signaling programs distinct cytokine profiles in naïve CD4+T cells by inducing AhR and c-MAF.
Databáze: Supplemental Index