| Autor: |
Cuénod, M., Sandri, Clara, Akert, K. |
| Zdroj: |
Journal of Cell Science; March 1970, Vol. 6 Issue: 2 p605-613, 9p |
| Abstrakt: |
The terminal degeneration of retino-tectal fibres was studied electron microscopically in the pigeon Synaptic vesicles seem to undergo systematic changes which can best be observed in aldehyde-fixed material. Initially (i.e. within 12–24 h) the vesicles begin to swell. The enlargement is clearly visible after 4 days (40 % increase in diameter) and reaches a maximum at 14 days (100% increase). At the latter stage, the enlargement is almost invariably associated with the well known opacity of degenerating terminals. In contrast, normal control tissue contains nerve endings with only a few enlarged and no ballooning vesicles. The conclusion seems warranted that the ballooning of synaptic vesicles is an early sign of terminal degeneration, it appears to precede vesicular disintegration. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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