| Autor: |
Maeyama, Yuka, Nakashima, Yuta, Kato, Hikaru, Hitora, Yuki, Maki, Kazuhiko, Inada, Natsumi, Murakami, Shunya, Inazumi, Tomoaki, Ise, Yuji, Sugimoto, Yukihiko, Ishikawa, Hayato, Tsukamoto, Sachiko |
| Zdroj: |
Journal of Natural Products; 20210101, Issue: Preprints |
| Abstrakt: |
A simple methylenedioxy dibromoindole alkaloid, amakusamine (1), was isolated from a marine sponge of the genus Psammocinia, and its structure was determined from spectroscopic data, time-dependent density-functional theory calculations, and synthesis. Compound 1inhibited the receptor activator of nuclear factor-κB ligand (RANKL)-induced formation of multinuclear osteoclasts with an IC50value of 10.5 μM in RAW264 cells. The structure–activity relationship of 1was also investigated with synthetic derivatives. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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