| Autor: |
Caligo, M A, Armstrong, W, Rossiter, B J, Meuth, M |
| Zdroj: |
Molecular and Cellular Biology; December 1990, Vol. 10 Issue: 12 p6805-6808, 4p |
| Abstrakt: |
The pattern of mutations produced by a mutator gene (obtained during serial selection for amplification of the dihydrofolate reductase [dhfr] locus) shows a pronounced shift from that found in wild-type cells. The rate of certain types of base substitutions (particularly transitions) is dramatically increased, while gene rearrangements constitute a lower proportion of mutations. These data suggest a lower fidelity of the replication process in the mutator strain. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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