| Autor: |
Mori-Quiroz, Luis M., Comadoll, Chelsea G., Super, Jonathan E., Clift, Michael D. |
| Zdroj: |
Organic Letters; 20210101, Issue: Preprints |
| Abstrakt: |
New methods for C–N bond construction exploiting the N-centered electrophilic character of iminoquinones are reported. Iminoquinones, generated in situvia the condensation of o-vinylanilines with benzoquinones, undergo acid-catalyzed cyclization to afford N-arylindoles in excellent yields. Under similar reaction conditions, homoallylic amines react analogously to afford N-arylpyrroles. Additionally, organometallic nucleophiles are shown to add to the nitrogen atom of N-alkyliminoquinones to provide amine products. Finally, iminoquinones are shown to be competent electrophiles for copper-catalyzed hydroamination. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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